Dr. Nilay Patel



PhD, The State University of New York, Stony Brook

BS, University of Cincinnati 

Research Areas

Drug discovery; cell cycle regulation; signal transduction; gene expression

Niclosamide is a FDA-approved drug with anti-proliferative effect on human cancer cell lines. Our research focuses on understanding different modes by which niclosamide reduces cell proliferation. In collaboration with Dr. de Lijser (Dept of Chemistry and Biochemistry, CSUF), we have designed a small library of compounds and identified compounds that have anti-proliferative effect. Niclosamide and some of the compounds designed at CSUF reduce b-catenin levels. Ongoing projects evaluate how these compounds affect different signal transduction pathways and gene expression of cell cycle-related proteins.


Peer Reviewed Publications

* = Patel lab undergraduate co-authors; # = Patel lab graduate co-authors


#Schott JT, * Mordaunt CE, *Vargas AJ, Leon MA, Chen KH, Singh M, Satoh M, Cardenas EL, Maitra S, Patel NV , de Lijser HJP (2013) Effects of structural and electronic characteristics of chalcones on the activation of peroxisome proliferator-activated receptor gamma (PPARγ). Chemical & Pharmaceutical Bulletin; 61(2):229-36. http://dx.doi.org/10.1248/cpb.c12-00749


Singh M, # Schott JT, Leon MA, Granata RT, Dhah HK, Welles JA, Boyce MA, Oseni-Olalemi HS, *Mordaunt CE, *Vargas AJ, Patel NV , Maitra S (2012) Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein-E production . Bioorganic & Medicinal Chemistry Letters; 22(19):6252-5. http://dx.doi.org/10.1371/journal.pone.0039329


*Kirby LA, # Schott JT, # Noble BL, *Mendez DC, Caseley PC, *Peterson SC, *Routledge TJ, Patel NV (2012) Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells. PLoS ONE, 7(6): e39329.http://dx.doi.org/10.1371/journal.pone.0039329

Grants & Special Projects

  • CIRM Bridges to Stem Cell Research Awards II (RFA 15-05; EDUC2-08382)

    Bridges to Stem Cell Research, Therapy and Careers: A Talent Development Program for Training Diverse Undergraduates for Careers in Regenerative Medicine