PhD, The State University of New York, Stony Brook
BS, University of Cincinnati
Drug discovery; cell cycle regulation; signal transduction; gene expression
Niclosamide is a FDA-approved drug with anti-proliferative effect on human cancer cell lines. Our research focuses on understanding different modes by which niclosamide reduces cell proliferation. In collaboration with Dr. de Lijser (Dept of Chemistry and Biochemistry, CSUF), we have designed a small library of compounds and identified compounds that have anti-proliferative effect. Niclosamide and some of the compounds designed at CSUF reduce b-catenin levels. Ongoing projects evaluate how these compounds affect different signal transduction pathways and gene expression of cell cycle-related proteins.
Courses Regularly Taught
Cellular and Molecular Biology (BIOL 151)
Advances in Cell Biology (BIOL 417)
Stem Cell Biology (BIOL 427)
Techniques in Stem Cell Biology (BIOL 429)
Stem Cell Proseminar (BIOL 480C)
Biological Internship (BIOL 495C)
*Kirby LA, *Schott JT, *Noble BL, *Mendez DC, Caseley PC, *Peterson SC, *Routledge TJ, Patel NV (2012) Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells. PLoS ONE 7(6): e39329. doi:10.1371/journal.pone.0039329.
Patel NV , Gordon MN, Connor KE, Good RA, Engelman RW, Mason J, Morgan DG, Morgan TE, Finch CE (2005) Caloric Restriction Slows Amyloid Accumulation in Transgenic Models of Alzheimer Disease. Neurobiology of Aging, 26: 995-1000.
Wong AM, Patel NV , Patel NK, Wei M, Morgan TE, de Beer MC, de Villiers WJ, Finch CE. (2005) Macrosialin increases during normal brain aging are attenuated by caloric restriction. Neuroscience Letters, 390: 76-80.
Patel NV , Wei M, Wong AM, Morgan TE, Finch CE (2004) Aging decreases glia-derived apolipoprotein-E and J secretion. Neuroscience Letters, 371:199-204.
Patel NV , Finch CE (2002) The glucocorticoid paradox of caloric restriction in slowing brain aging. Neurobiology of Aging, 23:707-717.
* indicates student co-author
Grants & Special Projects
Bridges to Stem Cell Research (BSCR) program