Phone: (657) 278-2471
Lab: DBH-145 and DBH-181
Phone: (657) 278-5294, -5297
Stevan PecicAssistant Professor Medicinal and Bioorganic Chemistry
Development of novel inhibitors of enzymes involved in lipid metabolism and their evaluation as potential therapeutics using traditional medicinal chemistry techniques (in silico drug design, synthesis, structure-activity relationship (SAR) studies and in vitro biological assays). We are also focused on the identification of DNA-aptameric sensors for small molecules in so-called structure-switching format using SELEX procedure. We are in particular interested in aptamers for small molecules such as steroids and drugs that regulate pain and inflammation. Aptamers generated via SELEX hold promise for bioimaging, drug development, drug discovery, disease diagnosis, hazard detection, food inspection and many other biomedical applications.
Postdoctoral- Columbia University Medical Center, New York
Ph.D. The City University of New York, Graduate School and University Center
M.Phil. The City University of New York, Graduate School and University Center
Dipl.Pharm. Faculty of Pharmacy, University of Belgrade, Serbia
Pecic, S; Zeki, AA; Xu, X; Jin, GY; Zhang, S; Kodani, S; Halim, M; Morisseau, C; Hammock, BD; Deng, SX. Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability Prostaglandins and Other Lipid Mediators, (2018) 136, 90-95.
Katz, FS; Pecic, S; Schneider, L; Zhu, Z; Hastings, A; Luzac, M; Macdonald, J; Landry, DW; Stojanovic, MN. New therapeutic approaches and novel alternatives for organophosphate toxicity Toxicology Letters, (2018) 291, 1-10.
Yang, KA; Chun, H; Zhang, Y; Pecic, S; Nakatsuka, N; Andrews, AM; Worgall, TS; Stojanovic, MN. High-Affinity Nucleic-Acid-Based Receptors for Steroids ACS Chemical Biology, (2017) 12(12), 3103-3112.
Tang, J; Ma, D; Pecic, S; Huang, C; Zheng, J; Li, J; Yang, R. Noninvasive and Highly Selective Monitoring of Intracellular Glucose via a Two-Step Recognition-Based Nanokit ACS Analytical Chemistry, (2017) 89(16), 8319-8327.
Šolaja, B.A., Terzic Jovanovic, N., Konstantinovic, J., Tot, M., Burojevic, J., Djurkovic Djakovic, O., Srbljanovic, J., Stajner, T., Verbic, T.Z., Zlatovic, M., Maia Machado, M.M., Albuquerque, I.S., Prudencio, M., Sciotti, R.J., Pecic, S., D’Alessandro, S., Taramelli, D. Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials? Journal of Medicinal Chemistry, (2016) 59 (1), p 264–281.
Katz, F.S., Pecic, S., Tran, T.H., Trakht, I., Schneider, L., Zhu, Z., Ton-That, L., Luzac, M., Zlatanic, V., Damera, S., Macdonald, J., Landry, D.D., Tong, L., Stojanovic, M.N. Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates. ChemBioChem, (2015) 16, 2205-2215.
Yang, K-A., Barbu, M., Halim, M., Pallavi, P., Kim, P., Kolpashchikov, D., Pecic, S., Taylor, S., Worgall, T., and Stojanovic, M.N. Recognition and Sensing of Low-Epitope Targets via Ternary Complexes with Oligonucleotides and Synthetic Receptors. Nature Chemistry, (2014) 6, 1003-1008.
Pecic, S., Pakhomova, S., Newcomer, M.E., Morisseau, C., Hammock, B.D., Zhu Z., Rinderspacher, A. and Deng, SX. Synthesis and structure–activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters, (2012) 23, (2), 417-421.
Pecic, S., Deng, SX., Morisseau, C., Hammock, B.D. and Landry, D.W. Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry Letters, (2012) 22, 601-605.
Pecic, S., McAnuff, M. and Harding, W.W. Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations. Journal of Enzyme Inhibition and Medicinal Chemistry, (2011) 26, (1), 46-55.
Pecic, S., Makkar, P., Chaudhary, S., Navarro, H.A., Reddy, B.V.B. and Harding, W.W. Affinity of aporphines for the human 5-HT2A receptor: Insights from homology modeling and molecular docking studies. Bioorganic and Medicinal Chemistry, (2010) 18, 5562-5575.
LeGendre, O., Pecic, S., Chaudhary, S., Zimmerman, S.M., Fantegrossi, W.E. and Harding, W.W. Synthetic studies and pharmacological evaluations on the MDMA ("Ecstasy") antagonist Nantenine. Bioorganic & Medicinal Chemistry Letters, (2010) 20, (2), 628-631.
Chaudhary, S., Pecic, S., LeGendre, O., Navarro, H.A. and Harding, W.W. (±)-Nantenine analogs as antagonists at human 5-HT2A receptors: C1 and flexible congeners. Bioorganic & Medicinal Chemistry Letters, (2009) 19, (9), 2530-2532.
Chaudhary, S., Pecic, S., LeGendre, O. and Harding, W.W. Microwave-Assisted Direct Biaryl Coupling: First Application to the Synthesis of Aporphines. Tetrahedron Letters, (2009) 50, (20), 2437-2439.
Chaudhary, S., Thomas, V., Todaro, L., LeGendre, O., Pecic, S., and Harding, W.W. New Drimane Sesquiterpenoids from Tidestromia oblongifolia. Natural Product Communications, 2008, 3, (11), 1747-1750.
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