Office: 580B
Phone: (657) 278-3594
Email: nsalzameda@fullerton.edu
Lab: DBH-182, -183
Phone: (657) 278-3913, -2596
Nicholas Salzameda
Professor, Organic and Bioorganic ChemistryResearch Interests
Our research interest is to synthesize and evaluate biologically active molecules as inhibitors for enzymes related to human health. This research includes designing enzymatic assays, structure activity relationship studies and computational docking. Diseases at the center of this research include West Nile virus, Botulism, Chagas disease and cancer.
Education
Postdoctoral, The Scripps Research Institute, La Jolla, CA (Professor Kim Janda)
Ph.D. University of Nevada, Reno (Professor David Lightner)
B.A. University of San Diego, California
Selected Publications
Amezcua, M.; Cruz, R.S.; Ku A.; Moran, W.; Ortega M.E.; Salzameda N. T.; "Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors". ACS Medical Chemistry Letters (2021) 12 (2), 295-301.
Thompson, J. C.; Dao, W. T.; Ku, A; Rodriguez-Beltran, S. L; Amezcua, M.; Palomino, A. Y.; Lien, T.; Salzameda, N. T. "Synthesis and Activity of Isoleucine Sulfonamide Derivatives as Novel Botulinum Neurotoxin Serotype A Light Chain Inhibitors". Bioorganic & Medicinal Chemistry (2020) 28, 115659.
Dooley, C. J; Burtea, A. Mitilian, C; Dao, W. T*.; Qu, B.; Salzameda, N. T.; Rychnovsk, S. D. "Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode’s Acylation Reagents". J. Org. Chem. (2020) 85, 10750.
Martinez AA, Espinosa BA, Adamek RN, Thomas BA, Chau J, Gonzalez E, Keppetipola N, Salzameda NT. "Breathing New Life Into West Nile Virus Therapeutics; Discovery and Study Of Zafirlukast as an NS2B-NS3 Protease Inhibitor". Eur J Med Chem. (2018) Sep 5;157:1202-1213.
Burtea A, Salzameda N. "Discovery and SAR Study of a Sulfonamide Hydroxamic Acid Inhibitor for the Botulinum Neurotoxin Serotype a Light Chain". Med. Chem. Commun. (2014) 5(6):706-710.
Lowery, C. A.; Salzameda, N. T.; Sawada, D.; Kaufmann, G. F.; Janda, K. D. “Medicinal Chemistry as a Conduit for the Modulation of Quorum Sensing”. J. Med. Chem. Accepted (2010).
Eubanks L.M.; Silhar, P, Salzameda, N.T.; Zakhari J. S.; Xiaochuan F.; Barbieri, J. T.; Shoemaker, C. B.; Hixon, M. S.; Janda, K. D. “Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease”. ACS Med. Chem. Lett. In press (2010)
Silhar, P.;Capkova, K.; Salzameda, N.T.; Barbieri, J.T.; Hixon M.S.; Janda, K.D. “Botulinum Neurotoxin Protease A: Discovery of Natural Product Exosite Inhibitor”. J. Am. Chem. Soc. (2010) 132, 2868-2869.
Salzameda, N.T.; Barbieri, J.T.; Janda, K.D. “Synthetic Substrate for Application in both High and Low Throughput Assays for Botulinum Neurotoxin B Protease Inhibitors”. Bioorg. Med. Chem. Lett. (2009) 19, 5848-5850.
Capkova, K.; Salzameda, N. T.; Janda, K. D., “Investigations into Small Molecule Non-peptidic Inhibitors of the Botulinum Neurotoxins”. Toxicon (2009) 54, 575-582.
Salzameda, N. T.; Lightner, D. A., “Intramolecular Hydrogen-Bonding in C(10) Homologated Bilirubinoids”. Monatsh. Chem. (2007) 138, 237-244.
Salzameda, N. T.; Huggins, M. T.; Lightner, D. A., “Novel N(23)-C(10)-Linked Linear Tetrapyrroles”. Tetrahedron (2006) 62, 9827-9831.
Courses Taught
Spring 2024 Office Hours
By appointment.
