Nicholas Salzameda, Ph.D.

Professor of Chemistry and Biochemistry

Office: MH-580B, Lab: DBH-182/183

Phone: 657-278-3594

Email: nsalzameda@fullerton.edu 

Lab website:

Dr. Salzameda obtained his Ph.D. at the University of Nevada, Reno. He undertook post-doctoral work at the Scripps Research Institute in La Jolla.

Research Interests

Our research interest is to synthesize and evaluate biologically active molecules as inhibitors for enzymes related to human health.  This research includes designing enzymatic assays, structure activity relationship studies and computational docking.  Diseases at the center of this research include West Nile virus, Botulism, Chagas disease and cancer.

Fun Fact

Dr. Salzameda loves to synthesize organic chemicals.

Publications

Amezcua, M.; Cruz, R.S.; Ku A.; Moran, W.; Ortega M.E.; Salzameda N. T.; "Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors". ACS Medical Chemistry Letters (2021) 12 (2), 295-301.

Thompson, J. C.; Dao, W. T.; Ku, A; Rodriguez-Beltran, S. L; Amezcua, M.; Palomino, A. Y.; Lien, T.; Salzameda, N. T. "Synthesis and Activity of Isoleucine Sulfonamide Derivatives as Novel Botulinum Neurotoxin Serotype A Light Chain Inhibitors". Bioorganic & Medicinal Chemistry (2020) 28, 115659.

Dooley, C. J; Burtea, A. Mitilian,  C; Dao, W. T*.; Qu, B.; Salzameda, N. T.; Rychnovsk, S. D. "Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode’s Acylation Reagents". J. Org. Chem. (2020) 85, 10750.

Martinez AA, Espinosa BA, Adamek RN, Thomas BA, Chau J, Gonzalez E, Keppetipola N, Salzameda NT. "Breathing New Life Into West Nile Virus Therapeutics; Discovery and Study Of Zafirlukast as an NS2B-NS3 Protease Inhibitor". Eur J Med Chem. (2018) Sep 5;157:1202-1213.

Burtea A, Salzameda N. "Discovery and SAR Study of a Sulfonamide Hydroxamic Acid Inhibitor for the Botulinum Neurotoxin Serotype a Light Chain". Med. Chem. Commun. (2014) 5(6):706-710.